Factors associated with a higher rate of distant failure after primary treatment for glioblastoma
| Autor: | Sonia, Tejada, Guillermo, Aldave, Miguel, Marigil, Jaime, Gállego Pérez-Larraya, Jaime, de Gallego, Pablo Daniel, Domínguez, Ricardo, Díez-Valle |
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| Jazyk: | angličtina |
| Předmět: |
Male
Oncology Fluorescence guided surgery Cancer Research Multivariate analysis medicine.medical_treatment Failure Tumor volume Promoter Regions Genetic DNA Modification Methylases medicine.diagnostic_test Brain Neoplasms Middle Aged Magnetic Resonance Imaging Dacarbazine Neurology Disease Progression Female Pattern of recurrence medicine.symptom Adjuvant medicine.drug medicine.medical_specialty Clinical Neurology Factors Lesion Text mining Internal medicine medicine Temozolomide Humans Karnofsky Performance Status Antineoplastic Agents Alkylating Radiotherapy business.industry Tumor Suppressor Proteins Magnetic resonance imaging Surgery Radiation therapy Treatment DNA Repair Enzymes Multivariate Analysis Clinical Study Neurology (clinical) Neoplasm Recurrence Local business Glioblastoma |
| Zdroj: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname Journal of Neuro-Oncology |
| ISSN: | 0167-594X |
| DOI: | 10.1007/s11060-013-1279-z |
| Popis: | Our purpose was to analyze the pattern of failure in glioblastoma (GBM) patients at first recurrence after radiotherapy and temozolomide and its relationship with different factors. From 77 consecutive GBM patients treated at our institution with fluorescence guided surgery and standard radiochemotherapy, 58 first recurrences were identified and included in a retrospective review. Clinical data including age, Karnofsky performance score, preoperative tumor volume and location, extend of resection, MGMT promoter methylation status, time to progression (PFS), overall survival (OS) and adjuvant therapies were reviewed for every patient. Recurrent tumor location respect the original lesion was the end point of the study. The recurrence pattern was local only in 65.5 % of patients and non-local in 34.5 %. The univariate and multivariate analysis showed that greater preoperative tumor volume in T1 gadolinium enhanced sequences, was the only variable with statistical signification (p |
| Databáze: | OpenAIRE |
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