Population-based study of treatment outcomes in squamous cell carcinoma of the retromolar trigone
| Autor: | Ahmed A. Abdoh, George K.B. Sándor, Richard W. Nason, Abdulaziz Binahmed |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Population medicine Carcinoma Humans education General Dentistry Survival rate Survival analysis Aged Maxillary Neoplasms education.field_of_study business.industry Retromolar Trigone medicine.disease Surgery Log-rank test Mandibular Neoplasms Treatment Outcome Otorhinolaryngology Epidermoid carcinoma Resection margin Carcinoma Squamous Cell Female Oral Surgery Neoplasm Recurrence Local business Epidemiologic Methods |
| Zdroj: | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 104(5) |
| ISSN: | 1528-395X |
| Popis: | Background Carcinoma of the retromolar trigone is relatively uncommon. High rates of local recurrence account for a relatively poor prognosis. Study design A population-based historical cohort of 76 cases with biopsy-proven squamous cell carcinoma of the retromolar trigone were studied as a case series. Kaplan-Meier survival curves and log rank test were used for statistical analysis. Results The mean age was 67.2 years. Fifty-six patients were male, 45% had T1 or T2 tumors, and 61% were staged as N0. Treatment included radiotherapy in 35%, surgery alone in 26%, surgery and radiotherapy in 23%, and 16% received palliative treatment. The absolute and disease-specific survivals at 5 years were 51.4% and 67.7%, respectively. In patients treated with surgery, the resection margin status predicted the overall 5-year survival ( P = .027), with 75% of patients with negative margins surviving 5 years versus a survival of 0% of patients with involved margins. Conclusions Squamous cell carcinoma of the retromolar trigone has a poor survival rate for early-stage disease. Adequate surgical margins can improve survival. |
| Databáze: | OpenAIRE |
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