Quantitative EEG After Brain Stimulation and Cognitive Training in Alzheimer Disease

Autor: Evgenya Dobronevsky, Jose Martin Rabey, Michael Khaigrekht, Sergio Aichenbaum, Revital Gandelman-Marton
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Time Factors
Physiology
medicine.medical_treatment
Audiology
Electroencephalography
Neuropsychological Tests
EEG-fMRI
Severity of Illness Index
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Physiology (medical)
medicine
Humans
0501 psychology and cognitive sciences
Aged
medicine.diagnostic_test
Cognitive Behavioral Therapy
business.industry
05 social sciences
Brain
Cognition
Signal Processing
Computer-Assisted
Quantitative electroencephalography
medicine.disease
Combined Modality Therapy
Transcranial Magnetic Stimulation
Cognitive training
Transcranial magnetic stimulation
Treatment Outcome
Neurology
Brain stimulation
Female
Neurology (clinical)
Alzheimer's disease
business
Mental Status Schedule
030217 neurology & neurosurgery
Zdroj: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 34(1)
ISSN: 1537-1603
Popis: Purpose Medications are the currently accepted symptomatic treatment of Alzheimer disease (AD), but their impact on delaying the progression of cognitive deficits and functional impairment is limited. The authors aimed to explore long-term electrophysiological effects of repetitive transcranial magnetic stimulation interlaced with cognitive training on quantitative electroencephalography (EEG) in patients with AD. Methods Quantitative EEG was assessed on non-repetitive transcranial magnetic stimulation interlaced with cognitive training treatment days before treatment and after each treatment phase in seven patients with mild AD. Results After 4.5 months (54 sessions) of treatment, a significant increase of delta activity over the temporal region was found compared with pretreatment values. Nonsignificant increases of the log EEG power were found for alpha band over the frontal and temporal regions, beta band over the frontal region, theta band over the frontal, temporal, and parieto-occipital regions, and delta band over the frontal and parieto-occipital regions. Nonsignificant decreases were found for alpha over the parieto-occipital region, and for beta over the temporal and parieto-occipital regions. A positive correlation was found between log alpha power over the frontal and temporal regions at 6 weeks and Mini-Mental State Examination (MMSE) scores at 6 weeks and 4.5 months, and between log alpha power over the parieto-occipital regions and MMSE scores at 6 weeks. A negative correlation was found between log alpha power over the frontal and temporal regions at 6 weeks and baseline Alzheimer's Disease Assessment Scale-cognitive subscale scores. Conclusions Repetitive transcranial magnetic stimulation interlaced with cognitive training has long-term effects on quantitative EEG in patients with mild AD. Further research on the quantitative EEG long-term effects of transcranial magnetic stimulation interlaced with cognitive training is required to confirm the authors' data.
Databáze: OpenAIRE
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