Clinical and biologic characterization of T-cell neoplasias with rearrangements of chromosome 7 band q34

Autor:	Rodman Morgan, Amylon, Michael P. Link, Roger A. Warnke, Bertil Glader, R Gemmell, Frederick Hecht, Stephen D. Smith, Charles A. Linker, BK Hecht
Rok vydání:	1988
Předmět:	Chromosome 7 (human) T cell T-cell receptor Immunology Chromosome Breakpoints Chromosome Chromosomal translocation Karyotype hemic and immune systems Cell Biology Hematology Biology Molecular biology Biochemistry Chromosome Band medicine.anatomical_structure Cancer research medicine
Zdroj:	Blood. 71:395-402
ISSN:	1528-0020 0006-4971
Popis:	In T cell malignancy, rearrangements of chromosome 14 have been observed with a break in the band that contains the alpha chain gene for the T cell receptor (TCR). Because the beta chain TCR gene is in chromosome band 7q34, we searched for and report finding specific rearrangements of 7q34 exclusively in T cell malignancies. The rearrangements were reciprocal translocations between 7q34 and other points: 1p34, 9q32, 9q34, 15q22, and 19p13. The malignancies containing a 7q34 translocation were either T cell acute lymphoblastic leukemias or T cell lymphoblastic lymphomas that had similarities in clinical, enzyme, immunologic, and cellular characteristics. Hybridization using a probe to the beta-TCR gene disclosed unique rearrangements consistent with clonality in every case. A common pattern with chromosome breakpoints involving TCR genes may be emerging in T cell neoplasia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4018426f512f03c82ec7d6a7604e28a3 https://doi.org/10.1182/blood.v71.2.395.bloodjournal712395 Zobrazit plný text záznamu