Clinical and biologic characterization of T-cell neoplasias with rearrangements of chromosome 7 band q34
Autor: | Rodman Morgan, Amylon, Michael P. Link, Roger A. Warnke, Bertil Glader, R Gemmell, Frederick Hecht, Stephen D. Smith, Charles A. Linker, BK Hecht |
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Rok vydání: | 1988 |
Předmět: | |
Zdroj: | Blood. 71:395-402 |
ISSN: | 1528-0020 0006-4971 |
Popis: | In T cell malignancy, rearrangements of chromosome 14 have been observed with a break in the band that contains the alpha chain gene for the T cell receptor (TCR). Because the beta chain TCR gene is in chromosome band 7q34, we searched for and report finding specific rearrangements of 7q34 exclusively in T cell malignancies. The rearrangements were reciprocal translocations between 7q34 and other points: 1p34, 9q32, 9q34, 15q22, and 19p13. The malignancies containing a 7q34 translocation were either T cell acute lymphoblastic leukemias or T cell lymphoblastic lymphomas that had similarities in clinical, enzyme, immunologic, and cellular characteristics. Hybridization using a probe to the beta-TCR gene disclosed unique rearrangements consistent with clonality in every case. A common pattern with chromosome breakpoints involving TCR genes may be emerging in T cell neoplasia. |
Databáze: | OpenAIRE |
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