Cortical recruitment determines learning dynamics and strategy
| Autor: | Brice Bathellier, Simon Rumpel, Aurélie Daret, Zuzanna Piwkowska, Thomas Deneux, Sebastian Ceballo, Pierre Pinson, Jacques Bourg, Alexandre Kempf |
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| Přispěvatelé: | Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institute of Physiology Focus Program Translational Neuroscience, Institut des Neurosciences de Paris-Saclay (Neuro-PSI) |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
genetic structures [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology General Physics and Astronomy 02 engineering and technology Stimulus Salience Discrimination Learning MESH: Optogenetics Mice Reinforcement learning MESH: Animals 10. No inequality lcsh:Science media_common Cerebral Cortex education.field_of_study Multidisciplinary [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences 021001 nanoscience & nanotechnology MESH: Reinforcement (Psychology) Auditory Perception Cues 0210 nano-technology Psychology Reinforcement Psychology media_common.quotation_subject Science Population Optogenetics Stimulus (physiology) Auditory cortex Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences MESH: Auditory Perception Salience (neuroscience) Perception Animals Learning education MESH: Mice Auditory Cortex General Chemistry MESH: Discrimination Learning MESH: Cerebral Cortex 030104 developmental biology MESH: Learning lcsh:Q MESH: Auditory Cortex Neuroscience MESH: Cues |
| Zdroj: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019) Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.1479. ⟨10.1038/s41467-019-09450-0⟩ Datacite Hyper Article en Ligne DOAJ-Articles PubMed Central |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-09450-0 |
| Popis: | Salience is a broad and widely used concept in neuroscience whose neuronal correlates, however, remain elusive. In behavioral conditioning, salience is used to explain various effects, such as stimulus overshadowing, and refers to how fast and strongly a stimulus can be associated with a conditioned event. Here, we identify sounds of equal intensity and perceptual detectability, which due to their spectro-temporal content recruit different levels of population activity in mouse auditory cortex. When using these sounds as cues in a Go/NoGo discrimination task, the degree of cortical recruitment matches the salience parameter of a reinforcement learning model used to analyze learning speed. We test an essential prediction of this model by training mice to discriminate light-sculpted optogenetic activity patterns in auditory cortex, and verify that cortical recruitment causally determines association or overshadowing of the stimulus components. This demonstrates that cortical recruitment underlies major aspects of stimulus salience during reinforcement learning. Sounds vary in the strength of behavioural conditioning they can evoke, a property attributed to stimulus salience. Here, the authors show that stimulus salience the overall level of neuronal activity recruited in the auditory cortex is strongly related with its reinforcing strength. |
| Databáze: | OpenAIRE |
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