Symptomatic Rathke Cleft Cyst in Pediatric Patients - Clinical Presentations, Surgical Treatment and Postoperative Outcomes - An Analysis of 38 Cases
| Autor: | Mieczyslaw Szalecki, Pawel Daszkiewicz, Monika Prokop-Piotrkowska, Agnieszka Bogusz-Wójcik, Marcin Roszkowski, Elzbieta Moszczynska |
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| Předmět: |
Delayed puberty
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Hypopituitarism Short stature Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Endocrinology Postoperative Complications Quality of life Polyuria medicine Humans Central Nervous System Cysts Child Retrospective Studies business.industry medicine.disease Rathke's pouch Surgery Treatment Outcome Surgical Procedures Operative Pediatrics Perinatology and Child Health Diabetes insipidus Female medicine.symptom business Polydipsia 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Publons |
| Popis: | Background: Rathke cleft cysts (RCC) are benign, epithelium-lined intrasellar and/or suprasellar cysts believed to originate from the remnants of the Rathke pouch. The aim of this study was to analyse the symptoms and surgical outcome of patients with the diagnosis of RCC verified in a histopathological examination of the postoperative material. Methods: The study is a retrospective analysis of 38 cases of children who underwent a neurosurgical treatment due to RCC at the Children’s Memorial Health Institute in Warsaw, Poland, between 1994 and 2015. Results: At diagnosis, the mean age was 13 years and 8 months (6 years and 11 months–17 years and 10 months, sex ratio was 1:0.9 with a female prevalence). The most common symptoms were the following: headache (50%), hypothyroidism (50%), short stature and/or decreased growth velocity (47%), delayed puberty and menstrual abnormalities (37%), diabetes insipidus or polydipsia and polyuria (26%), adrenal dysfunction (26%), sleepiness and general weakness (13%) and visual disturbances (11%). Due to the gravity of symptoms and size of the lesion, all the patients underwent a surgical treatment. All but one were successful (one patient died due to postoperative neurosurgical complications). The most common postoperative complications were the following: adenohypopituitarism (67%) and diabetes insipidus (45%). Conclusions: RCC can present with serious symptoms that significantly deteriorate patients’ quality of life. Despite a successful neurosurgical treatment in most of the analysed cases, patients required long-term pharmacological treatment. |
| Databáze: | OpenAIRE |
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