Middle East respiratory syndrome coronavirus (MERS-CoV) — Surveillance and testing in North England from 2012 to 2019

Autor: Malcolm Guiver, Andrew Turner, Shazaad Ahmad, Louise M Hesketh, Emma Davies, Nicholas Machin, Hamzah Z. Farooq
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
viruses
medicine.disease_cause
Polymerase Chain Reaction
law.invention
chemistry.chemical_compound
MERS-CoV
High consequence infectious disease
0302 clinical medicine
EID
law
030212 general & internal medicine
Respiratory system
Child
Pathogen
Polymerase chain reaction
Aged
80 and over
General Medicine
Middle Aged
HCID
Infectious Diseases
England
Child
Preschool
Epidemiological Monitoring
Emerging infectious disease
Middle East Respiratory Syndrome Coronavirus
Female
medicine.symptom
Coronavirus Infections
Travel-Related Illness
Microbiology (medical)
Adult
Oseltamivir
Adolescent
Middle East respiratory syndrome coronavirus
030106 microbiology
Antiviral Agents
Virus
Article
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Middle East
Young Adult
MERS
Influenza
Human
medicine
Humans
lcsh:RC109-216
Aged
Retrospective Studies
Public health epidemiological surveillance
business.industry
Infant
Virology
chemistry
Sputum
business
Zdroj: International Journal of Infectious Diseases, Vol 93, Iss, Pp 237-244 (2020)
International Journal of Infectious Diseases
ISSN: 1201-9712
Popis: Highlights • MERS is an emerging infectious disease with high consequences. • PHE Manchester receives a high number of MERS surveillance samples. • Sputum samples are the optimum samples for diagnosing respiratory viruses. • Multiple samples per patient result in a 100% diagnostic yield and a confirmed end-diagnosis.
Background Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in Saudi Arabia in 2012 and caused an epidemic in the Middle East. Public Health England (PHE) Manchester is one of the two PHE centres in the UK that perform testing for MERS-CoV. The results of the PHE Manchester MERS surveillance from 2012 to 2019 are presented in this report. Methods Retrospective data were collected for returning travellers from the Middle East fitting the PHE MERS case definition. Respiratory samples were tested for respiratory viruses and MERS-CoV using an in-house RT-PCR assay. Results Four hundred and twenty-six (426) samples from 264 patients were tested for MERS Co-V and respiratory viruses. No MERS-CoV infections were identified by PCR. Fifty-six percent of samples were PCR positive for viral or bacterial pathogen with Influenza A as the predominant virus (44%). Sixty-two percent of all patients had a pathogen identified with the highest positivity from sputum samples. Patients with multiple samples demonstrated a 100% diagnostic yield. Conclusions Although no cases of MERS were identified, the majority of patients had Influenza infection for which oseltamivir treatment was indicated and isolation warranted. Sputum samples were the most useful in diagnosing respiratory viruses with a 100% diagnostic yield from patients with multiple samples.
Databáze: OpenAIRE
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