Hypercalcemia in Malignant Paraganglioma due to Parathyroid Hormone-Related Protein
| Autor: | Alonzo J. Flores, Theodore R. Miller, Francisco A. Bracho, Ali Kaviani, Katherine K. Matthay, Keh-Chuan Loh, David C. Price, Felix A. Conte, Margo Hoover, Dolores M. Shoback, Craig T. Albanese, Alan B. Cortez |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Intact parathyroid hormone Pamidronate Malignancy Paraganglioma Endocrinology Internal medicine medicine Humans Malignant Paraganglioma Retroperitoneal Neoplasms Diphosphonates Parathyroid hormone-related protein business.industry Parathyroid Hormone-Related Protein Proteins Parathyroid chief cell medicine.disease Pediatrics Perinatology and Child Health Hypercalcemia Tomography X-Ray Computed business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Hormone Research in Paediatrics. 50:217-221 |
| ISSN: | 1663-2826 1663-2818 |
| Popis: | A 15-year-old boy had hypercalcemia in association with malignant retroperitoneal paraganglioma. He had suppressed circulating levels of intact parathyroid hormone, whereas parathyroid hormone-related protein (PTHrP) immunoreactivity was elevated in plasma. Both the serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were normal. Preoperatively the patient required control of hypercalcemia with intravenous pamidronate therapy. His circulating calcium and PTHrP concentrations became normal after a successful surgical resection of the primary retroperitoneal tumor. To our knowledge, this is the first reported case of elevated PtHrP levels in a patient with paraganglioma which resolved postoperatively. |
| Databáze: | OpenAIRE |
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