Disrupted prefrontal regulation of striatum-related craving in Internet gaming disorder revealed by dynamic causal modeling: results from a cue-reactivity task
| Autor: | Hui Zheng, Guangheng Dong, Ziliang Wang, Min Wang, Xiaoxia Du, Marc N. Potenza |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Lentiform nucleus media_common.quotation_subject Prefrontal Cortex Craving Gyrus Cinguli Lateralization of brain function Executive Function Young Adult 03 medical and health sciences 0302 clinical medicine Reward medicine Humans Applied Psychology Anterior cingulate cortex media_common Brain Mapping Addiction Bayes Theorem Cognition Magnetic Resonance Imaging Corpus Striatum 030227 psychiatry Behavior Addictive Psychiatry and Mental health medicine.anatomical_structure Video Games Cue reactivity Posterior cingulate Female Cues medicine.symptom Psychology Neuroscience Internet Addiction Disorder 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine. 51:1549-1561 |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundStudies of Internet gaming disorder (IGD) suggest an imbalanced relationship between cognitive control and reward processing in people with IGD. However, it remains unclear how these two systems interact with each other, and whether they could serve as neurobiological markers for IGD.MethodsFifty IGD subjects and matched individuals with recreational game use (RGU) were selected and compared when they were performing a cue-craving task. Regions of interests [anterior cingulate cortex (ACC), lentiform nucleus] were selected based on the comparison between brain responses to gaming-related cues and neutral cues. Directional connectivities among these brain regions were determined using Bayesian estimation. We additionally examined the posterior cingulate cortex (PCC) in a separate analysis based on data implicating the PCC in craving in addiction.ResultsDuring fixed-connectivity analyses, IGD subjects showed blunted ACC-to-lentiform and lentiform-to-ACC connectivity relative to RGU subjects, especially in the left hemisphere. When facing gaming cues, IGD subjects trended toward lower left-hemispheric modulatory effects in ACC-to-lentiform connectivity than RGU subjects. Self-reported cue-related craving prior to scanning correlated inversely with left-hemispheric modulatory effects in ACC-to-lentiform connectivity.ConclusionsThe results suggesting that prefrontal-to-lentiform connectivity is impaired in IGD provides a possible neurobiological mechanism for difficulties in controlling gaming-cue-elicited cravings. Reduced connectivity ACC-lentiform connectivity may be a useful neurobiological marker for IGD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|