A Polymorphism in the Serotonin Receptor 3A (HTR3A) Gene and Its Association With Harm Avoidance in Women
| Autor: | Per Björntorp, Roland Rosmond, Fariba Baghaei, Jonas Melke, Göran Holm, Lars-Göran Nilsson, Rolf Adolfsson, Henrik Soderstrom, Lars Westberg, Staffan Nilsson, Elias Eriksson, Mikael Landén |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Karolinska Scales of Personality medicine.medical_specialty Genotype Personality Inventory media_common.quotation_subject Personality Assessment Cohort Studies Arts and Humanities (miscellaneous) HTR3B medicine Humans Personality Psychiatry media_common Sweden Polymorphism Genetic biology Aggression Serine Endopeptidases Middle Aged medicine.disease Psychiatry and Mental health biology.protein Harm avoidance Female Temperament and Character Inventory Temperament Receptors Serotonin 5-HT3 medicine.symptom Personality Assessment Inventory Psychology Clinical psychology |
| Zdroj: | Archives of General Psychiatry. 60:1017 |
| ISSN: | 0003-990X |
| Popis: | BACKGROUND: The brain neurotransmitter serotonin is known to affect various aspects of human behavior, including personality traits. Serotonin receptor type 3 is a ligand-gated channel encoded by 2 different subunit genes, HTR3A and HTR3B. A polymorphism (C178T) in the 5' region of the HTR3A gene has recently been identified and suggested to be of functional importance. OBJECTIVE: To elucidate the possible association between the C178T polymorphism in the HTR3A gene and personality traits in women. DESIGN: Two independent samples of 35- to 45-year-old Swedish women were recruited using the population register. Sample 1 (n = 195) was assessed via the Karolinska Scales of Personality and the Temperament and Character Inventory; sample 2 (n = 175) was assessed using the latter only. Both samples were genotyped with respect to the C178T polymorphism in the HTR3A gene. The A1596G polymorphism in the same gene was also investigated. RESULTS: A significant association between C178T genotype and the Temperament and Character Inventory factor harm avoidance was observed in sample 1 (corrected for multiple comparisons P =.04); this finding was subsequently replicated in sample 2 (P =.004) (pooled populations: P |
| Databáze: | OpenAIRE |
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