Expression of TLR3, 4, 7 and 9 in cutaneous malignant melanoma: relationship with clinicopathological characteristics and prognosis
| Autor: | Belen Fernandez-Garcia, Luis O. González, Francisco J. Vizoso, Noemi Eiro, C. Ovies, C. C. Álvarez-Cuesta, Lucía González |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Time Factors Dermatology Kaplan-Meier Estimate Disease-Free Survival Young Adult Biomarkers Tumor Medicine Humans Clinical significance Receptor Melanoma Aged Aged 80 and over Chi-Square Distribution business.industry TLR9 General Medicine Middle Aged medicine.disease Immunohistochemistry Toll-Like Receptor 3 Up-Regulation Toll-Like Receptor 4 Treatment Outcome Toll-Like Receptor 7 Tumor progression Toll-Like Receptor 8 TLR4 Female business Immunostaining |
| Zdroj: | Archives of dermatological research. 305(1) |
| ISSN: | 1432-069X |
| Popis: | Toll-like receptors (TLRs) have achieved an extraordinary amount of interest in cancer research due to their role in tumor progression. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, 7 and 9 in cutaneous malignant melanoma (CMM). The expression levels of TLR3, 4, 7 and 9 were analyzed in tumors from 30 patients with CMM. The analysis was performed by immunohistochemistry, and the results were correlated with various clinicopathological findings and with relapse-free survival. Our results indicate that there was a wide variability in the immunostaining score values for each receptor. Positive staining for TLRs was generally found in tumor cells, especially for TLR4 and TLR9. Nevertheless, a significant percentage of tumors also showed TLR4 expression in mononuclear inflammatory cells (62.1 %) and in fibroblast-like cells (34.5 %). Our results showed no significant association between score values for each TLR and clinicopathological characteristics of patients. However, our results demonstrated that high TLR4 expression was significantly associated with a shortened relapse-free survival (p = 0.001). Therefore, TLR4 expression may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma. |
| Databáze: | OpenAIRE |
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