Comparative study of optical coherence tomography angiography algorithms for rodent retinal imaging
Autor: | Shuliang Jiao, Dhruba Paudel, Arash Dadkhah |
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Rok vydání: | 2021 |
Předmět: |
Materials science
Computed Tomography Angiography Fundus Oculi Phase (waves) 01 natural sciences General Biochemistry Genetics and Molecular Biology Retina 010309 optics Complexity index Rats Sprague-Dawley 03 medical and health sciences Mice 0302 clinical medicine Imaging Three-Dimensional Optical coherence tomography Phase variance 0103 physical sciences medicine Image Processing Computer-Assisted Animals Original Research medicine.diagnostic_test Retinal Vessels Ear Optical coherence tomography angiography Rats Vessel diameter Microangiography Blood Circulation Microvessels 030221 ophthalmology & optometry Retinal imaging Algorithm Algorithms Tomography Optical Coherence |
Zdroj: | Exp Biol Med (Maywood) |
ISSN: | 1535-3699 |
Popis: | Optical coherence tomography angiography (OCTA) is a functional extension of optical coherence tomography for non-invasive in vivo three-dimensional imaging of the microvasculature of biological tissues. Several algorithms have been developed to construct OCTA images from the measured optical coherence tomography signals. In this study, we compared the performance of three OCTA algorithms that are based on the variance of phase, amplitude, and the complex representations of the optical coherence tomography signals for rodent retinal imaging, namely the phase variance, improved speckle contrast, and optical microangiography. The performance of the different algorithms was evaluated by comparing the quality of the OCTA images regarding how well the vasculature network can be resolved. Quantities that are widely used in ophthalmic studies including blood vessel density, vessel diameter index, vessel perimeter index, vessel complexity index were also compared. Results showed that both the improved speckle contrast and optical microangiography algorithms are more robust than phase variance, and they can reveal similar vasculature features while there are statistical differences in the calculated quantities. |
Databáze: | OpenAIRE |
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