Electroacupuncture at Baihui (DU20) acupoint up-regulates mRNA expression of NeuroD molecules in the brains of newborn rats suffering in utero fetal distress
| Autor: | Jian-wen Xu, Yan Liu, Lu Chen, Wei Wang, Qiao-mei Lin, Lan Xue |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty hypoxic-ischemic brain injury Electroacupuncture medicine.medical_treatment Mrna expression NeuroD Electro acupuncture Baihui (DU20) acupoint lcsh:RC346-429 nerve regeneration brain injury in utero fetal distress electroacupuncture real-time fluorescent quantitative PCR nerve repair non-acupoint neural regeneration 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Internal medicine Fetal distress medicine lcsh:Neurology. Diseases of the nervous system business.industry medicine.disease Neural stem cell 030104 developmental biology Real-time polymerase chain reaction Endocrinology In utero embryonic structures business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Neural Regeneration Research, Vol 11, Iss 4, Pp 604-609 (2016) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | NeuroD plays a key regulatory effect on differentiation of neural stem cells into mature neurons in the brain. Thus, we assumed that electroacupuncture at Baihui (DU20) acupoint in newborn rats exposed to in utero fetal distress would influence expression of NeuroD. Electroacupuncture at Baihui was performed for 20 minutes on 3-day-old (Day 3) newborn Sprague-Dawley rats exposed to in utero fetal distress; electroacupuncture parameters consisted of sparse and dense waves at a frequency of 2-10 Hz. Real-time fluorescent quantitative PCR results demonstrated that mRNA expression of NeuroD, a molecule that indicates NeuroD, increased with prolonged time in brains of newborn rats, and peaked on Day 22. The level of mRNA expression was similar between Day 16 and Day 35. These findings suggest that electro acupuncture at Baihui acupoint could effectively increase mRNA expression of molecules involved in NeuroD in the brains of newborn rats exposed to in utero fetal distress. |
| Databáze: | OpenAIRE |
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