Heterolytic Benzene C−H Activation by a Cyclometalated Iridium(III) Dihydroxo Pyridyl Complex: Synthesis, Hydrogen−Deuterium Exchange, and Density Functional Study

Autor:	Daniel H. Ess, Jonas Oxgaard, William J. Tenn, William A. Goddard, Kenneth J. H. Young, Steven K. Meier, Roy A. Periana
Rok vydání:	2009
Předmět:	Organic Chemistry chemistry.chemical_element Photochemistry Medicinal chemistry Heterolysis Inorganic Chemistry chemistry.chemical_compound chemistry Deuterium Pyridine Hydrogen–deuterium exchange Density functional theory Iridium Physical and Theoretical Chemistry Benzene Metal aquo complex
Zdroj:	Organometallics. 28:5293-5304
ISSN:	1520-6041 0276-7333
DOI:	10.1021/om900039s
Popis:	We report the synthesis of the pincer-cyclometalated (NNC^(t-Bu))Ir(III) dihydroxo pyridyl complex 6, which catalyzes hydrogen−deuterium (H/D) exchange between water and benzene in the presence of base (TOF = ~6 × 10^(−3) s^(−1) at 190 °C). Experimental and density functional theory (B3LYP) studies suggest that H/D exchange occurs through loss of pyridine followed by benzene coordination and C−H bond activation by a heterolytic substitution mechanism to give a phenyl aquo complex, which may dimerize. Exchange of H_2O for D_2O followed by the microscopic reverse of CH activation leads to deuterium incorporation into benzene. Synthesis of the μ-hydroxo phenyl dinuclear complex [(NNC^(t-Bu))Ir(Ph)(μ-OH)]_2 (9) also catalyzes H/D exchange with a turnover frequency (TOF = ~7 × 10^(−3) s^(−1) at 190 °C) similar to that for 6.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400997d59e46cff7f4a66e4e8e90f1c0 https://doi.org/10.1021/om900039s Zobrazit plný text záznamu