Recognition in the Face of Diversity: Interactions of Heterotrimeric G proteins and G Protein-coupled Receptor (GPCR) Kinases with Activated GPCRs
| Autor: | Chih Chin Huang, John J.G. Tesmer |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Protein Folding
G protein-coupled receptor kinase GTPase-activating protein G protein Minireviews Cell Biology Biology G-Protein-Coupled Receptor Kinases Heterotrimeric GTP-Binding Proteins Biochemistry Rhodopsin-like receptors Cell biology Enzyme Activation G beta-gamma complex Heterotrimeric G protein Animals Humans Molecular Biology hormones hormone substitutes and hormone antagonists G alpha subunit G protein-coupled receptor |
| Zdroj: | Journal of Biological Chemistry. 286:7715-7721 |
| ISSN: | 0021-9258 |
| DOI: | 10.1074/jbc.r109.051847 |
| Popis: | G protein-coupled receptors (GPCRs) represent the largest class of integral membrane protein receptors in the human genome. Despite the great diversity of ligands that activate these GPCRs, they interact with a relatively small number of intracellular proteins to induce profound physiological change. Both heterotrimeric G proteins and GPCR kinases are well known for their ability to specifically recognize GPCRs in their active state. Recent structural studies now suggest that heterotrimeric G proteins and GPCR kinases identify activated receptors via a common molecular mechanism despite having completely different folds. |
| Databáze: | OpenAIRE |
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