COVID-19 vaccination hesitancy and safety among adult people with epilepsy in eastern China

Autor: Shan, Wang, Jin, Lv, Chenmin, He, Yuyu, Yang, Yuanyuan, Zheng, Lingqi, Ye, Cong, Chen, Chunhong, Shen, Sha, Xu, Yao, Ding, Yi, Guo, Yelei, Tang, Shuang, Wang, Meiping, Ding
Rok vydání: 2023
Předmět:
Zdroj: Epilepsy & Behavior. 138:108984
ISSN: 1525-5050
Popis: This study assesses the hesitancy and safety of vaccination administration for the novel 2019 Coronavirus Disease (COVID-19) among adult people with epilepsy (PWE).We recruited adult PWE who visited the outpatient epilepsy clinic from August 2021 to February 2022. We administered a structured questionnaire and a face-to-face interview regarding demographic factors, epilepsy characteristics, and relevant vaccine issues to all patients. Factors related to receiving a vaccine and epilepsy-related events after vaccination were then analyzed.A total of 501 PWE were surveyed; 288 were unvaccinated and 213 were vaccinated. Patients without jobs (OR: 0.59; 95% CI: 0.37-0.95, p = 0.03) were less likely to receive the vaccine compared to students or those with jobs. Other factors associated with vaccination were a higher number of anti-seizure medications (OR: 0.72; 95% CI: 0.55-0.95, p = 0.02) and a lower pre-vaccine seizure frequency (OR: 2.21; 95% CI: 1.06-4.59, p = 0.03). Of the 213 vaccinated patients, 10 (4.70%) reported at least one local and/or systemic side effect. Most patients (92.50%) did not report worse seizures within one month of vaccination. Poor ASM adherence (OR: 15.06; 95% CI: 1.75-129.87, p = 0.01) and fatigue/stimulant drinks such as caffeine (OR: 50.59; 95% CI: 7.57-337.94, p 0.01) were significantly associated with seizure worsening within one month of receiving the COVID-19 vaccination.Almost two-fifths of patients with adult PWE have received a COVID-19 vaccine. Attention should be paid to educating epilepsy patients without jobs on the significance and safety of the vaccine. There was a low risk of seizure worsening in the short term after vaccination in PWE.
Databáze: OpenAIRE
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