(18)F-DCFPyL PET/CT Imaging in Patients with Biochemically Recurrent Prostate Cancer After Primary Local Therapy
| Autor: | Philip Eclarinal, Yolanda McKinney, Maria Liza Lindenberg, Janet F. Eary, Venkatesh Krishnasamy, Ismael Baris Turkbey, Esther Mena, Bradford J. Wood, Ilhan Lim, Stephen Adler, Stephanie Harmon, Richard Chang, Elliot Levy, Peter L. Choyke, Maria J. Merino, William L. Dahut, Joanna H. Shih, Peter A. Pinto, Deborah Citrin, Frank I. Lin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Biochemical recurrence
medicine.medical_specialty Prostatectomy business.industry medicine.medical_treatment Urology Histology urologic and male genital diseases medicine.disease Theranostics Primary tumor 030218 nuclear medicine & medical imaging Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Bed 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging Lymph business |
| Zdroj: | J Nucl Med |
| Popis: | Our objective was to investigate the lesion detection rate of (18)F-DCFPyL PET/CT, a prostate-specific membrane antigen (PSMA)–targeted PET agent, in patients with biochemically relapsed prostate cancer after primary local therapy. Methods: This was a prospective institutional review board–approved study of 90 patients with documented biochemical recurrence (median prostate-specific antigen [PSA], 2.5 ng/mL; range, 0.21–35.5 ng/mL) and negative results on conventional imaging after primary local therapies, including radical prostatectomy (n = 38), radiation (n = 27), or a combination of the two (n = 25). Patients on androgen deprivation therapy were excluded. Patients underwent whole-body (18)F-DCFPyL PET/CT (299.9 ± 15.5 MBq) at 2 h after injection. The PSMA PET lesion detection rate was correlated with PSA, PSA kinetics, and original primary tumor grade. Results: Seventy patients (77.8%) showed positive PSMA PET results, with a total of 287 lesions identified: 37 prostate bed foci, 208 lesions in lymph nodes, and 42 in distant sites in bones or organs, Eleven patients had negative results, and 9 patients showed indeterminate lesions, which were considered negative in this study. The detection rates were 47.6% (n = 10/21), 50% (n = 5/10), 88.9% (n = 8/9), and 94% (n = 47/50) for PSA levels of >0.2 to |
| Databáze: | OpenAIRE |
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