CCN1 secreted by human adipose-derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway

Autor: Yi Yang, Shiyi Li, Xuer Sun, Lixia Zhang, Minliang Chen, Huijuan Fu
Rok vydání: 2022
Předmět:
Zdroj: International wound journalREFERENCES.
ISSN: 1742-481X
Popis: The study aimed to explore the role of cellular communication network factor 1 (CCN1) an extracellular matrix protein in hADSC-treated wound healing. Immunofluorescence and enzyme-linked immunosorbent assays (ELISA) were used to demonstrate the secretion of CCN1 by hADSCs, isolated from human fat tissue. We investigated the role of CCN1 in wound healing by knockdown of CCN1 expression in hADSCs using CCN1 siRNA. Conditioned medium of hADSCs or hADSCs with CCN1 knocked down (hADSC-CM
Databáze: OpenAIRE