Associations of epithelial sodium channel genes with blood pressure: the GenSalt study
| Autor: | F Liu, X Yang, X Mo, J Huang, J Chen, T N Kelly, J E Hixson, D C Rao, C C Gu, L C Shimmin, T K Rice, J Li, K Schwander, J He, D-p Liu, D Gu |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Epithelial sodium channel China medicine.medical_specialty Mean arterial pressure hypertension Adolescent GenSalt Diastole Blood Pressure Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Article Young Adult Asian People Gene Frequency Risk Factors Internal medicine Internal Medicine medicine Humans Genetic Predisposition to Disease Allele Epithelial Sodium Channels Gene Allele frequency Genetic Association Studies Aged Aged 80 and over Genetics genetic variants Middle Aged Protective Factors 3. Good health Phenotype Endocrinology Blood pressure epithelial sodium channel Female |
| Zdroj: | Journal of human hypertension |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/jhh.2014.78 |
| Popis: | In order to investigate the associations of SCNN1A, SCNN1G and SCNN1B genes with blood pressure (BP) in the Han Chinese population, we included 2880 participants did not use antihypertensive medication in the month prior to the baseline survey in the current analysis. Forty-four tag-single-nucleotide polymorphisms (SNPs) in epithelial sodium channel (ENaC) genes were selected and genotyped, and nine BP measurements were obtained during the 3-day examination. In the single-marker analyses, we identified significant associations of SCNN1A marker rs13306613 with diastolic BP (DBP) and SCNN1B marker rs12447134 with systolic BP (SBP) under codominant model after Bonferroni's correction (P=2.82 × 10(-5) and 4.63 × 10(-4), respectively). In addition, five SNPs in SCNN1G and four SNPs in SCNN1B achieved nominal significance for SBP, DBP or mean arterial pressure (MAP) under the additive model. For example, the minor C allele of rs5735 in SCNN1G gene was associated with decreased SBP, DBP and MAP (P=0.016, 5.41 × 10(-3) and 4.36 × 10(-3), respectively). Gene-based results showed significant associations of SCNN1G and SCNN1B with BP levels. This study suggested that ENaC genes have important roles in BP regulation in the Han Chinese population. Future studies are warranted to replicate these findings, and functional studies are needed to identify true causal variants in ENaC genes. |
| Databáze: | OpenAIRE |
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