Magnetic Susceptibility Difference-Induced Nucleus Positioning in Gradient Ultrahigh Magnetic Field
| Autor: | Xin Zhang, Hanxiao Chen, Xuyao Han, Lei Zhang, Qingping Tao, Xinmiao Ji |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Biophysics
Biomagnetism law.invention 03 medical and health sciences Paramagnetism Magnetics 0302 clinical medicine Nuclear magnetic resonance law medicine Humans 030304 developmental biology Physics Superconductivity 0303 health sciences Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms Articles equipment and supplies Magnetic susceptibility Magnetic field SQUID medicine.anatomical_structure Magnetic Fields Cytoplasm Nucleus human activities 030217 neurology & neurosurgery |
| Zdroj: | Biophysical Journal |
| ISSN: | 1542-0086 0006-3495 |
| Popis: | Despite the importance of magnetic properties of biological samples for biomagnetism and related fields, the exact magnetic susceptibilities of most biological samples in their physiological conditions are still unknown. Here we used SQUID (Superconducting Quantum Interferometer Device) to detect the magnetic properties of non-fixed non-dehydrated live cell and cellular fractions, at a physiological temperature of 37 °C (310 K). It is obvious that there are paramagnetic components within human nasopharyngeal carcinoma CNE-2Z cells. More importantly, the magnetic properties of cytoplasm and nucleus are different. Although within a single cell, the magnetic susceptibility difference between cellular fractions (nucleus and cytoplasm) could only cause ∼41-130 pN forces to nucleus by gradient ultra-high magnetic fields of 13.1-23.5 T, 92-160 T/m, these forces are enough to cause a relative position shift of the nucleus within the cell. This not only demonstrates the importance of magnetic susceptibility in the biological effects of magnetic field, but also illustrates the potential application of high magnetic fields in biomedicine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|