Supplementary Figures 1 - 4, Tables 1 - 2 from Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors

Autor: Alan C. Sartorelli, Yashang Lee, Margaret E. Whicker, Elena S. Ratner, Z. Ping Lin
Rok vydání: 2023
Popis: PDF file - 128K, Fig. S1. BRCA1 and BRCA2-defective EOC cells are sensitive to triapine. Fig. S2. Triapine abrogates olaparib-induced RPA phosphorylation in SKOV-3 cells. Fig. S3. Depletion of Chk1 partially reverses the inhibitory effects of triapine on RPA32 and CtIP phosphorylation. Fig. S4. Depletion of CtIP by siRNA. Table S1. CI values of triapine and olaparib combination determined by MTS viability assay in NTC and BRCA1-kd SKOV3 cells. Table S2A. CI values of triapine and olaparib combination at a constant ratio in NTC and BRCA1-kd SKOV3 cells (Fig. 2A). Table S2B. CI values of triapine and olaparib combination in SKOV-3 cells (Fig. 2B). Table S2C. CI values of triapine and olaparib combination in BG-1 cells (Fig. 2C). Table S2D. CI values of triapine and olaparib combination in PEO4 cells (Fig. 2D).
Databáze: OpenAIRE