Regulation of Immunity in Clear Cell Renal Carcinoma: Role of PD-1, PD-L1, and PD-L2
| Autor: | Evgeny A Usynin, L. V. Spirina, Zahar Yurmazov, Ekaterine Ladutko, Irina V Kondakova, Evgeny Choynzonov |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
PD-L1 PD-L2 QH301-705.5 Programmed Cell Death 1 Receptor urologic and male genital diseases Microbiology B7-H1 Antigen Metastasis primary tumor PD-1 medicine kidney cancers metastasis Humans Biology (General) Neoplasm Metastasis Molecular Biology Protein kinase B Carcinoma Renal Cell PI3K/AKT/mTOR pathway Retrospective Studies molecular factors biology business.industry Immunity Cancer General Medicine Middle Aged medicine.disease Programmed Cell Death 1 Ligand 2 Protein Primary tumor female genital diseases and pregnancy complications Kidney Neoplasms Tumor progression Von Hippel-Lindau Tumor Suppressor Protein Cancer research biology.protein business Clear cell |
| Zdroj: | Current Issues in Molecular Biology Volume 43 Issue 2 Pages 76-1080 Current Issues in Molecular Biology, Vol 43, Iss 76, Pp 1072-1080 (2021) |
| ISSN: | 1467-3045 |
| Popis: | Regulation of immunity is a unique oncogenic mechanism that differs in different cancers. VHL deficient clear cell renal cell carcinomas (ccRCC) trigger the immune response resulting in cancer progression. This study aimed to investigate PD-1, PD-L1, and PD-L2 expression in ccRCC primary cancers and metastatic tissues associated with the p-VHL content, transcriptional, and growth factors expression. Methods: A total of 62 patients with RCC were enrolled in the study. Investigation of mRNA level was performed by PCR in real-time. Western blotting analysis was used for detecting the p-VHL protein content in tissues. Results: The PD-L2 prevalence in metastatic cancers is crucial in tumor progression. The VHL expression and p-VHL content determined the aggressive cancer behavior and elevated in disseminated tumors. The cancer dissemination was accompanied by an increase in both mRNA and VHL content. Conclusion: We present a new instrument targeting pathologies with p-VHL/HIF altered function that impact the PD-L2 expression through the change in transcriptional, growth factors, and AKT/mTOR modulation. |
| Databáze: | OpenAIRE |
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