Lysosomal phospholipase A(1) in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas' disease
| Autor: | J. Florin-Christensen, Marisa J. Wainszelbaum, Joaquin Juan Bautista Cannata, Monica Florin-Christensen, Silvina Elizabeth Wilkowsky, Estela Isola |
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| Předmět: |
Chagas disease
Programmed cell death Trypanosoma cruzi Endogeny Biology Biochemistry Catalysis Phospholipases A Pathogenesis Phospholipase A1 parasitic diseases medicine Animals Humans Chagas Disease Molecular Biology Phospholipids chemistry.chemical_classification Phospholipase A Cell Biology biology.organism_classification medicine.disease Phospholipases A1 Enzyme chemistry Lysosomes Research Article |
| Zdroj: | ResearcherID |
| Popis: | We found that, as in African trypanosomes, endogenous phospholipase A1 (Plase A1) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A1 was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A1 emerges as a target to block pathogenesis in trypanosomal infections. |
| Databáze: | OpenAIRE |
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