Comparative genome mapping of the deer mouse (Peromyscus maniculatus) reveals greater similarity to rat (Rattus norvegicus) than to the lab mouse (Mus musculus)
| Autor: | Clifton M. Ramsdell, Paul B. Vrana, Adrienne Lewandowski, Michael J. Dewey, Rachel J. O’Neill, Julie L Weston Glenn |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
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Rodent Genetic Linkage animal diseases phylogeny Genome Polymerase Chain Reaction Mice 0302 clinical medicine Deer mouse medicine.vector_of_disease humans database Genomic organization Expressed Sequence Tags 0303 health sciences biology Chromosome Mapping Life Sciences comparative maps rodents Research Article Genetic Markers Peromyscus DNA Complementary Evolution Zoology Synteny Evolution Molecular 03 medical and health sciences Gene mapping Species Specificity biology.animal parasitic diseases evolution medicine QH359-425 Animals mammals Ecology Evolution Behavior and Systematics 030304 developmental biology cats Laboratory mouse homology biology.organism_classification Rats stomatognathic diseases 030217 neurology & neurosurgery |
| Zdroj: | Ramsdell, Clifton M; Lewandowski, Adrienne A; Glenn, Julie Weston; Vrana, Paul B; O'Neill, Rachel J; & Dewey, Michael J. (2008). Comparative genome mapping of the deer mouse (Peromyscus maniculatus) reveals greater similarity to rat (Rattus norvegicus) than to the lab mouse (Mus musculus). BMC Evolutionary Biology, 8, 65-65. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1vj2h64t BMC Evolutionary Biology, Vol 8, Iss 1, p 65 (2008) BMC Evolutionary Biology |
| Popis: | Background Deer mice (Peromyscus maniculatus) and congeneric species are the most common North American mammals. They represent an emerging system for the genetic analyses of the physiological and behavioral bases of habitat adaptation. Phylogenetic evidence suggests a much more ancient divergence of Peromyscus from laboratory mice (Mus) and rats (Rattus) than that separating latter two. Nevertheless, early karyotypic analyses of the three groups suggest Peromyscus to be exhibit greater similarities with Rattus than with Mus. Results Comparative linkage mapping of an estimated 35% of the deer mouse genome was done with respect to the Rattus and Mus genomes. We particularly focused on regions that span synteny breakpoint regions between the rat and mouse genomes. The linkage analysis revealed the Peromyscus genome to have a higher degree of synteny and gene order conservation with the Rattus genome. Conclusion These data suggest that: 1. the Rattus and Peromyscus genomes more closely represent ancestral Muroid and rodent genomes than that of Mus. 2. the high level of genome rearrangement observed in Muroid rodents is especially pronounced in Mus. 3. evolution of genome organization can operate independently of more commonly assayed measures of genetic change (e.g. SNP frequency). |
| Databáze: | OpenAIRE |
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