Allergic contact dermatitis caused by hydroperoxides of limonene and dose‐response relationship—A repeated open application test (ROAT) study
| Autor: | Lina Hagvall, Jeanne D. Johansen, Johanna Bråred Christensson, Niels H. Bennike, Claus Zachariae, Lina Palangi, Ulrika Nilsson |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Dermatology Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Internal medicine Humans Immunology and Allergy Medicine In patient Clinical significance 030212 general & internal medicine Allergic contact dermatitis Limonene Dose-Response Relationship Drug business.industry Patch test Hydrogen Peroxide Allergens Middle Aged Patch Tests medicine.disease Perfume Dose–response relationship chemistry Contact allergy Dermatitis Allergic Contact Monoterpenes Female business |
| Zdroj: | Contact Dermatitis. 80:208-216 |
| ISSN: | 1600-0536 0105-1873 |
| DOI: | 10.1111/cod.13168 |
| Popis: | BACKGROUND Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim-OOHs) as the main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions have been reported. OBJECTIVES To determine the clinical relevance, elicitation threshold and dose-response relationship of Lim-OOHs in individuals with a positive or doubtful patch test reaction to standard Lim-OOHs 0.3% pet. METHODS A multicentre 3-week double-blind vehicle-controlled repeated open application test (ROAT) study with a simulated fine fragrance containing Lim-OOHs at 1260, 420 and 140 ppm, equal to a dose/area per application of Lim-OOHs of 3.0, 0.99 and 0.33 μg/cm2 , was performed. RESULTS Among 11 subjects allergic to Lim-OOHs, 11 (100%), 7 (64%), and 3 (27%), respectively, reacted to the applied doses. No reactions were seen in 17 healthy controls exposed to the highest dose. This difference in reactivity was statistically significant (P |
| Databáze: | OpenAIRE |
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