The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats

Autor: Sevil Eraslan, Osman Ciftci, Ercan Yilmaz, Nese Basak, Asli Cetin, Rauf Melekoglu
Rok vydání: 2018
Předmět:
0301 basic medicine
medicine.medical_treatment
Uterus
antioxidant activity
Pharmacology
Wistar rat
medicine.disease_cause
Antioxidants
chemistry.chemical_compound
Random Allocation
0302 clinical medicine
biochemical analysis
Malondialdehyde
oxidative stress
rat
animal
glutathione
glutathione peroxidase
uterus disease
Uterine Diseases
adult
catalase
drug effect
malonaldehyde
Animals
Antineoplastic Agents
Alkylating/*adverse effects
Antioxidants/*pharmacology
Capsaicin/*pharmacology
Catalase/analysis
Curcumin/*pharmacology
Cyclophosphamide/*adverse effects
Female
Glutathione/analysis
Glutathione Peroxidase/analysis
Malondialdehyde/analysis
Oxidative Stress/drug effects
Rats
Wistar
Reproducibility of Results
Superoxide Dismutase/analysis
Uterine Diseases/chemically induced/prevention & control
Uterus/*drug effects/pathology
cell degeneration
Catalase
superoxide dismutase
Glutathione
medicine.anatomical_structure
female
030220 oncology & carcinogenesis
histopathology
microscopy
chemically induced
Antioxidant
medicine.drug
Curcumin
RD1-811
Cyclophosphamide
animal experiment
randomization
Article
animal tissue
03 medical and health sciences
evaluation study
medicine
controlled study
reproducibility
Antineoplastic Agents
Alkylating
Chemotherapy
Glutathione Peroxidase
nonhuman
uterus
business.industry
Superoxide Dismutase
animal model
Therapeutic effect
Rats
alkylating agent
tissue injury
Oxidative Stress
030104 developmental biology
chemistry
Capsaicin
Surgery
cell vacuole
pathology
business
Oxidative stress
Zdroj: Acta Cirúrgica Brasileira v.33 n.6 2018
Acta Cirúrgica Brasileira
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
Acta Cirurgica Brasileira, Volume: 33, Issue: 6, Pages: 499-507, Published: JUN 2018
Acta Cirurgica Brasileira, Vol 33, Iss 6, Pp 499-507 (2018)
ISSN: 1678-2674
Popis: Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin. © 2018, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.
Databáze: OpenAIRE
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