tLyP-1-conjugated Au-nanorod@SiO(2) core-shell nanoparticles for tumor-targeted drug delivery and photothermal therapy
| Autor: | Guanbin Song, Yang Ju, Baiyao Xu, Yanbin Cui, Yuichi Iwase, Atsushi Hosoi, Yasuyuki Morita |
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| Rok vydání: | 2014 |
| Předmět: |
Nanotechnology
Nanomaterials Cell Line HeLa Drug Delivery Systems Electrochemistry medicine Humans General Materials Science Spectroscopy Nanotubes biology Chemistry Mesenchymal stem cell Surfaces and Interfaces Photothermal therapy Phototherapy Condensed Matter Physics biology.organism_classification Silicon Dioxide Cell culture Drug delivery Biophysics Nanoparticles Nanorod Camptothecin medicine.drug |
| Zdroj: | Langmuir : the ACS journal of surfaces and colloids. 30(26) |
| ISSN: | 1520-5827 |
| Popis: | Mesoporous silica-coated Au nanorod (AuNR@SiO2) is one of the most important appealing nanomaterials for cancer therapy. The multifunctions of chemotherapy, photothermal therapy, and imaging of AuNR@SiO2 make it very useful for cancer therapy. In this study, AuNR@SiO2 was functionalized to deliver hydrophobic antitumor drug and to heat the targeted tumor with the energy of near-infrared (NIR). To carry out the function of targeting the tumor, tLyP-1, a kind of tumor homing and penetrating peptide, was engrafted to AuNR@SiO2. The fabricated AuNR@SiO2-tLyP-1 which was loaded with camptothecin (CPT) showed a robust, selective targeting and penetrating efficiency to Hela and MCF-7 cells and induced the death of these cells. When the micromasses of these AuNR@SiO2-tLyP-1 internalized cells were irradiated by NIR illumination, all the cells were killed instantaneously owing to the increased temperature caused by the surface plasma resonance (SPR) of the internalized AuNR@SiO2-tLyP-1. Moreover, the systematic toxicity of CPT-loaded AuNR@SiO2-tLyP-1 on human mesenchymal stem cells (hMSCs) was minimized, because the AuNR@SiO2-tLyP-1 selectively targeted and penetrated into the tumor cells, and little hydrophobic CPT was released into the culture medium or blood. This study indicates that the AuNR@SiO2-tLyP-1 drug delivery system (DDS) has great potential application for the chemo-photothermal cancer therapy. |
| Databáze: | OpenAIRE |
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