Cell Surface Delivery of the Measles Virus Nucleoprotein: a Viral Strategy To Induce Immunosuppression
| Autor: | T. Fabian Wild, Branka Horvat, Jean-Michel Escola, Julien C. Marie, Pierre Jurdic, Frédéric Saltel |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Paramyxoviridae
viruses Immunology Dermatitis Contact Microbiology Virus Measles virus Viral Proteins 03 medical and health sciences 0302 clinical medicine Immune system Morbillivirus Virology Immune Tolerance Humans Mononegavirales Measles Virus Nucleoprotein 030304 developmental biology 0303 health sciences biology Interleukin-12 Subunit p40 Cell Membrane Receptors IgG Nucleocapsid Proteins biology.organism_classification Interleukin-12 Endocytosis 3. Good health Nucleoprotein Protein Subunits Nucleoproteins Insect Science Pathogenesis and Immunity 030215 immunology |
| Zdroj: | Journal of Virology. 78:11952-11961 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.78.21.11952-11961.2004 |
| Popis: | Although only a few blood cells are infected during measles, this infectious disease is followed by acute immunosuppression, associated with high infant mortality. Measles virus nucleoprotein has been suggested to contribute to virus-induced inhibition of the immune response. However, it has been difficult to understand how this cytosolic viral protein could leave an infected cell and then perturb the immune response. Here we demonstrate that intracellularly synthesized nucleoprotein enters the late endocytic compartment, where it recruits its cellular ligand, the Fcγ receptor. Nucleoprotein is then expressed at the surfaces of infected leukocytes associated with the Fcγ receptor and is secreted into the extracellular compartment, allowing its interaction with uninfected cells. Finally, cell-derived nucleoprotein inhibits the secretion of interleukin-12 and the generation of the inflammatory reaction, both shown to be impaired during measles. These results reveal nucleoprotein egress from infected cells as a novel strategy in measles-induced immunosuppression. |
| Databáze: | OpenAIRE |
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