Factors Associated With Racial/Ethnic Group–Based Medical Mistrust and Perspectives on COVID-19 Vaccine Trial Participation and Vaccine Uptake in the US
| Autor: | Heidi Gustine, Sheena Cresswell, Mark Manning, Jamie A. Mitchell, Curtis Lipscomb, Seongho Kim, Lisa M Saigh, Jametta Y Lilly, Felicity W. K. Harper, Hayley S. Thompson, Lisa Rutledge, Madiha Tariq, Annie Sanders, Shoma Pal, Kristopher Johns, Nadia Sayed, Brittany Dowe, Megan Landry, Bertram Marks |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Michigan COVID-19 Vaccines Adolescent Cross-sectional study media_common.quotation_subject Ethnic group Trust Racism White People Young Adult Vaccination Refusal Health care Medicine Humans Rejection (Psychology) Young adult health care economics and organizations media_common Original Investigation Aged Clinical Trials as Topic Asian business.industry Research Racial Groups Vaccine trial COVID-19 General Medicine Hispanic or Latino Middle Aged Patient Acceptance of Health Care Vaccination Black or African American Online Only Cross-Sectional Studies Female Public Health business Attitude to Health Demography |
| Zdroj: | JAMA Network Open |
| ISSN: | 2574-3805 |
| Popis: | This survey study of adults residing in Michigan during June to December 2020 examines associations between race/ethnicity, medical mistrust within racial/ethnic groups, and willingness to participate in COVID-19 vaccine trials or to receive a COVID-19 vaccine. Key Points Question Is there an association between race/ethnicity and rejection of COVID-19 vaccine trial participation and vaccine uptake in the US, and does racial/ethnic group–based medical mistrust mediate this association? Findings In this survey study of 1835 adults in Michigan, Black participants reported the greatest medical mistrust among the racial/ethnic groups surveyed. Analysis of path models revealed significantly greater COVID-19 vaccine trial and uptake rejection among Black participants, which was partially mediated by medical mistrust. Meaning The findings suggest that racial/ethnic group–based medical mistrust may partially explain the association between Black race/ethnicity and rejection of COVID-19 vaccine trial participation and uptake, potentially informing socially and culturally responsive efforts to promote COVID-19 vaccination in this group. Importance The impact of COVID-19 in the US has been far-reaching and devastating, especially in Black populations. Vaccination is a critical part of controlling community spread, but vaccine acceptance has varied, with some research reporting that Black individuals in the US are less willing to be vaccinated than other racial/ethnic groups. Medical mistrust informed by experiences of racism may be associated with this lower willingness. Objective To examine the association between race/ethnicity and rejection of COVID-19 vaccine trial participation and vaccine uptake and to investigate whether racial/ethnic group–based medical mistrust is a potential mediator of this association. Design, Setting, and Participants This cross-sectional survey study was conducted from June to December 2020 using a convenience sample of 1835 adults aged 18 years or older residing in Michigan. Participants were recruited through community-based organizations and hospital-academic networks. Main Outcomes and Measures Separate items assessed whether respondents, if asked, would agree to participate in a research study to test a COVID-19 vaccine or to receive a COVID-19 vaccine. Participants also completed the suspicion subscale of the Group-Based Medical Mistrust Scale. Results Of the 1835 participants, 1455 (79%) were women, 361 (20%) men, and 19 (1%) other gender. The mean (SD) age was 49.4 (17.9) years, and 394 participants (21%) identified as Black individuals. Overall, 1376 participants (75%) reported low willingness to participate in vaccine trials, and 945 (52%) reported low willingness to be vaccinated. Black participants reported the highest medical mistrust scores (mean [SD], 2.35 [0.96]) compared with other racial/ethnic groups (mean [SD] for the total sample, 1.83 [0.91]). Analysis of path models revealed significantly greater vaccine trial and vaccine uptake rejection among Black participants (vaccine trial: B [SE], 0.51 [0.08]; vaccine uptake: B [SE], 0.51 [0.08]; both P |
| Databáze: | OpenAIRE |
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