Mechanisms of Synaptic Vesicle Exocytosis
| Autor: | Richard H. Scheller, Richard C. Lin |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Vesicle fusion
Vesicular Transport Proteins Nerve Tissue Proteins Biology Membrane Fusion Exocytosis Synaptotagmin 1 Synaptotagmins Munc18 Proteins Animals Humans Phosphorylation Membrane Glycoproteins Calcium-Binding Proteins Membrane Proteins SNAP25 Munc-18 Intracellular vesicle Cell Biology Kiss-and-run fusion rab3A GTP-Binding Protein Cell biology Synaptic vesicle exocytosis Calcium Synaptic Vesicles Soluble NSF attachment protein Carrier Proteins SNARE Proteins Signal Transduction Developmental Biology |
| Zdroj: | Annual Review of Cell and Developmental Biology. 16:19-49 |
| ISSN: | 1530-8995 1081-0706 |
| DOI: | 10.1146/annurev.cellbio.16.1.19 |
| Popis: | ▪ Abstract Chemical synaptic transmission serves as the main form of cell to cell communication in the nervous system. Neurotransmitter release occurs through the process of regulated exocytosis, in which a synaptic vesicle releases its contents in response to an increase in calcium. The use of genetic, biochemical, structural, and functional studies has led to the identification of factors important in the synaptic vesicle life cycle. Here we focus on the prominent role of SNARE (soluble NSF attachment protein receptor) proteins during membrane fusion and the regulation of SNARE function by Rab3a, nSec1, and NSF. Many of the proteins important for transmitter release have homologs involved in intracellular vesicle transport, and all forms of vesicle trafficking share common basic principles. Finally, modifications to the synaptic exocytosis pathway are very likely to underlie certain forms of synaptic plasticity and therefore contribute to learning and memory. |
| Databáze: | OpenAIRE |
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