The association of body mass index, weight gain and central obesity with activity-related breathlessness: the Swedish Cardiopulmonary Bioimage Study
| Autor: | Hanan A Tanash, Magnus Sköld, Göran Bergström, Kjell Torén, Annika Rosengren, Klas Gränsbo, Lars Nilsson, Eva Lindberg, John Brandberg, Lennart Persson, Johan Sundström, Eva Swahn, Carl Johan Östgren, Jan Engvall, Anna-Carin Olin, Ulf Nilsson, Anders Blomberg, Maria Eriksson, Martin Sandelin, Gunnar Engström, Kenneth Caidahl, Stefan Söderberg, Magnus Ekström, Tomas Jernberg, Tomas Hansen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Population Weight Gain Health outcomes Body Mass Index Forced Expiratory Volume Internal medicine medicine Humans Lung volumes education Lung Lung function Sweden education.field_of_study business.industry Incidence Smoking Middle Aged respiratory system Prognosis medicine.disease Obesity Cross-Sectional Studies Dyspnea Obesity Abdominal Female medicine.symptom business Weight gain Body mass index |
| Zdroj: | Thorax. 74:958-964 |
| ISSN: | 1468-3296 0040-6376 |
| Popis: | IntroductionBreathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear.MethodsThis population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score ≥1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex.ResultsWe included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m2; and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; pConclusionBreathlessness is independently associated with obesity and with weight gain in adult life, and the association is stronger for individuals with lower lung volumes. |
| Databáze: | OpenAIRE |
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