Idiopathic hypoparathyroidism and Addison's disease
| Autor: | Abraham R. Kantrowitz, Martin Perlmutter, Rose Ruth Ellison, Luigia Norsa |
|---|---|
| Rok vydání: | 1956 |
| Předmět: |
medicine.medical_specialty
Hypoparathyroidism Parathyroid Diseases chemistry.chemical_element Calcium Parathyroid Glands Addison Disease Internal medicine medicine Adrenal insufficiency Humans Disease Adrenocortical Insufficiency business.industry General Medicine medicine.disease Endocrinology chemistry Hypoadrenocorticism Familial Addison's disease Cortisone business Dihydrotachysterol Adrenal Insufficiency medicine.drug Hormone |
| Zdroj: | The American Journal of Medicine. 21:634-643 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(56)90078-x |
| Popis: | 1.1. The clinical findings, results of metabolic studies and autopsy data on a patient presenting both adrenocortical insufficiency and hypoparathyroidism, are recorded. This is the second known report in which concurrence of these two disorders was established by both clinical and pathologic data. There are published reports of four other similar cases but pathologic data are lacking and some of the clinical data are not complete. 2.2. The adrenocortical function of the patient in this report was studied before and during adequate therapy for hypoparathyroidism. No apparent difference was noted in the adrenocortical function in the hypocalcemic state when compared with the period of normal serum calcium concentration. 3.3. Increasing doses of parathormone, up to 500 units per day, failed to alter the level of serum or urine calcium and phosphate. However, when 1,000 units of parathormone were injected per day the concentration of serum calcium rose, serum phosphate fell, and the urinary excretion of both phosphate and calcium rose. Dihydrotachysterol and calcium ingestion resulted in maintenance of normal serum calcium levels. 4.4. The available data concerning the pituitary-parathyroid interrelationship are reviewed. It would appear that no specific pituitary parathyrotropic hormone has been demonstrated. However, there is evidence to suggest that the pituitary hormones, notably growth hormones, induce a rise in the serum phosphate level and thus stimulate parathyroid activity. 5.5. The available data concerning the adrenocortical-parathyroid interrelationship are also reviewed. Clinical observations fail to confirm certain experimental data indicating that adrenocortical insufficiency ameliorates the hypoparathyroid state. However, excess cortisone administration may aggravate the manifestations of hypoparathyroidism. |
| Databáze: | OpenAIRE |
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