Increased expression of dopamine receptors on lymphocytes in Parkinson's disease
| Autor: | Giovanni Fabbrini, Laura Felici, Gian Luigi Lenzi, Giuseppe Meco, Caterina Calderaro, Piero Barbanti, Elena Bronzetti, Fabrizio Stocchi, Francesco Amenta, Alberto Ricci, Rosanna Cerbo, Brunella Caronti |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Levodopa Parkinson's disease Cell Count Binding Competitive Sensitivity and Specificity Receptors Dopamine Antiparkinson Agents Radioligand Assay Dopamine receptor D3 Dopamine Internal medicine medicine Humans Lymphocytes Receptor Aged business.industry Dopaminergic Brain Parkinson Disease Middle Aged medicine.disease Magnetic Resonance Imaging Bromocriptine Endocrinology Treatment Outcome Neurology Dopamine receptor Dopamine Agonists Female Neurology (clinical) business medicine.drug |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society. 14(5) |
| ISSN: | 0885-3185 |
| Popis: | Dopamine D1-like and D2-like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjects (multiple-system atrophy, n = 16; essential tremor, n = 10; other neurodegenerative diseases, n = 10), and in 26 healthy control subjects by radioligand binding assay techniques using [3H]SCH 23390 and [3H]7OH-DPAT as ligands. Patients with PD revealed a higher density (Bmax) of dopamine D1-like (p |
| Databáze: | OpenAIRE |
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