Investigation of vascular endothelial growth factor (VEGF) polymorphism in patients with idiopathic heavy menstrual bleeding
| Autor: | Nur Semerci Gündüz, Ikbal Kaygusuz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Vascular Endothelial Growth Factor A
Turkish population medicine.medical_specialty Genotype VEGF receptors Gastroenterology Polymorphism Single Nucleotide chemistry.chemical_compound Polymorphism (computer science) Internal medicine Medicine Humans Genetic Predisposition to Disease Allele skin and connective tissue diseases Menorrhagia biology business.industry Haplotype Obstetrics and Gynecology General Medicine Vascular endothelial growth factor Menstrual bleeding chemistry Case-Control Studies biology.protein Female business human activities |
| Zdroj: | Archives of gynecology and obstetrics. 305(1) |
| ISSN: | 1432-0711 |
| Popis: | Purpose: To investigate whether there is a relationship between the VEGF gene polymorphisms and idiopathic heavy menstrual bleeding (HMB-E).Methods: 65 patients diagnosed with HMB-E according to the FIGO classification system and 65 female healty volunteers were included in the study. Detection of rs699947 (-2578C>A), rs1570360 (-1154G>A), rs2010963 (+405G>C), rs3025039 (+936C>T), rs25648 (c534C>T) polymorphic regions of the VEGF gene was performed by Next Generation DNA Sequencing method.Results: the -2578C>A polymorphic region CC, CA+AA genotypes, and C allele, as well as the -1154G>A polymorphic region AA genotype, and A allele were associated with increased risk of HMB-E (all pC, +936C>T, c534C>T polymorphic regions (all p>0.05). While the -2578/-1154/+405/c534 AGGC haplotype decreased the risk of HMB-E, CAGC haplotype was found to increase the risk of HMB-E.Conclusion: VEGF -2578C>A and -1154G>A polymorphisms were significantly associated with the risk of HMB-E in the Turkish population. |
| Databáze: | OpenAIRE |
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