Chicken IL-6 is a heat-shock gene
| Autor: | Mitsuaki Fujimoto, Akira Nakai, Ryosuke Takii, Naoki Hayashida, Sachiye Inouye, Ke Tan, Ramachandran Prakasam, Eiichi Takaki, Fangxu Wu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Fever
Molecular Sequence Data Biophysics Chicken Cells Inflammation Biology Biochemistry Avian Proteins Structural Biology Heat shock protein HSF Genetics medicine Animals Heat shock HSF1 Interleukin 6 Molecular Biology Gene Heat-Shock Proteins ATF3 IL-6 Activating Transcription Factor 3 Base Sequence Interleukin-6 Cell Biology Molecular biology Cell biology biology.protein Trans-Activators medicine.symptom Chickens Heat-Shock Response |
| Zdroj: | FEBS letters. 587(21) |
| ISSN: | 1873-3468 |
| Popis: | The febrile response is elicited by pyrogenic cytokines including IL-6 in response to microorganism infections and diseases in vertebrates. Mammalian HSF1, which senses elevations in temperature, negatively regulates the response by suppressing pyrogenic cytokine expression. We here showed that HSF3, an avian ortholog of mammalian HSF1, directly binds to and activates IL-6 during heat shock in chicken cells. Other components of the febrile response mechanism, such as IL-1β and ATF3, were also differently regulated in mammalian and chicken cells. These results suggest that the febrile response is exacerbated by a feed-forward circuit composed of the HSF3-IL-6 pathway in birds. |
| Databáze: | OpenAIRE |
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