Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance
| Autor: | Himavanth R. Gatla, Kartick C. Pramanik, Manoj K. Pandey, Monish Ram Makena, Dattesh Verlekar, Sahithi Sukhavasi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
therapeutic resistance Wnt/β-catenin signaling pathway Angiogenesis Carcinogenesis pancreatic cancer Wnt pathway inhibitors Drug resistance Review Culprit Models Biological Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Pancreatic cancer medicine Animals Humans Molecular Targeted Therapy Physical and Theoretical Chemistry Molecular Biology Wnt Signaling Pathway lcsh:QH301-705.5 Spectroscopy business.industry Organic Chemistry Wnt signaling pathway Cancer General Medicine medicine.disease Computer Science Applications Pancreatic Neoplasms 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Apoptosis Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research business Adult stem cell |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 17, p 4242 (2019) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Pancreatic ductal adenocarcinoma (PDAC) is responsible for 7.3% of all cancer deaths. Even though there is a steady increase in patient survival for most cancers over the decades, the patient survival rate for pancreatic cancer remains low with current therapeutic strategies. The Wnt/β-catenin pathway controls the maintenance of somatic stem cells in many tissues and organs and is implicated in pancreatic carcinogenesis by regulating cell cycle progression, apoptosis, epithelial-mesenchymal transition (EMT), angiogenesis, stemness, tumor immune microenvironment, etc. Further, dysregulated Wnt has been shown to cause drug resistance in pancreatic cancer. Although different Wnt antagonists are effective in pancreatic patients, limitations remain that must be overcome to increase the survival benefits associated with this emerging therapy. In this review, we have summarized the role of Wnt signaling in pancreatic cancer and suggested future directions to enhance the survival of pancreatic cancer patients. |
| Databáze: | OpenAIRE |
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