Microwave-assisted synthesis of indole-derivatives via cycloisomerization of 2-alkynylanilines in water without added catalysts, acids, or bases

Autor:	Adriano Carpita, Arianna Ribecai
Rok vydání:	2009
Předmět:	Indole test Green chemistry chemistry.chemical_classification Cycloisomerization Base (chemistry) chemistry Organic Chemistry Drug Discovery Metal catalyst Biochemistry Microwave assisted Combinatorial chemistry Catalysis
Zdroj:	Tetrahedron Letters. 50:6877-6881
ISSN:	0040-4039
Popis:	An unprecedented green methodology is described for the preparation of differently substituted indoles via microwave-assisted cycloisomerization of 2-alkynylaniline derivatives in water. Moderate to good yields in the cyclization can be achieved for a variety of 2-aminoaryl alkynes. Reactions are run without any added metal catalyst, acid, or base, and do not take place by applying conventional heating.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe8beccd89359b34e14473187770ba1 https://doi.org/10.1016/j.tetlet.2009.09.135 Zobrazit plný text záznamu Full Text from ScienceDirect