We report successful liver transplantation in a young adult with argininosuccinic aciduria but without cirrhosis. Plasma amino acid profile normalised and brain magnetic resonance spectroscopy indicated improved metabolism post transplantation. The general well being of the patient and his quality of life have improved. We suggest that orthotopic liver transplantation should be considered for patients with Argininosuccinic aciduria even in the absence of cirrhosis with the aim of correcting (at least in part) central nervous system metabolism thereby preventing further neurological deterioration.
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