Prepulse Inhibition of Acoustic Startle and the Influence of Methylphenidate in Children With ADHD
| Autor: | Alexander Baumgarten-Walczak, Julia Gebhardt, Paul Eggert, Anja Thiemann, Sebastian Schulz-Juergensen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Reflex Startle medicine.medical_specialty Adolescent Audiology Placebo behavioral disciplines and activities Double-Blind Method Enuresis mental disorders Developmental and Educational Psychology medicine Humans Attention deficit hyperactivity disorder Deamino Arginine Vasopressin Prospective Studies Child Psychiatry Prepulse inhibition Cross-Over Studies Methylphenidate Reactive Inhibition medicine.disease Crossover study Comorbidity Clinical Psychology Treatment Outcome Acoustic Stimulation Attention Deficit Disorder with Hyperactivity Concomitant Central Nervous System Stimulants Female medicine.symptom Psychology medicine.drug |
| Zdroj: | Journal of Attention Disorders. 18:117-122 |
| ISSN: | 1557-1246 1087-0547 |
| DOI: | 10.1177/1087054712448960 |
| Popis: | Objective: ADHD is common among children with comorbidity of enuresis. Findings concerning prepulse inhibition (PPI) of startle reflexes are controversial. Although PPI is improved through desamino-arginine vasopressin (dDAVP) in enuresis, some patients also improve concomitant ADHD through dDAVP. This study aims to evaluate whether methylphenidate (MPH) also improves PPI in ADHD. Method: Nineteen ADHD patients were investigated in a prospective, double-blind, crossover study with MPH versus placebo. PPI was measured as a reduction of acoustic startle reflexes. Subgroups of gender, ADHD subtype, and baseline PPI were analyzed. Results: Median baseline PPI of ADHD patients (51.7%) was below the value of age-matched normal controls (73%, p = .090). MPH showed no improvement in the whole group, or the subgroups gender or subtype. Reduced baseline PPI was significantly improved (22.5%-39.3%, p = .039). Conclusion: Heterogeneity of ADHD is confirmed with a wide range of baseline PPI. The improvement of reduced baseline PPI through MPH suggests impaired sensorimotor gating in this subgroup. |
| Databáze: | OpenAIRE |
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