The effects of omepmzole and cimetidine on duodenal ulcer healing and ihe relief of symptoms
| Autor: | S. DAHLGREN, L DOMELLÖF, M. HRADSKY, C. NORRYD, J. BRUNKWALL, G. SVENSSON, J.-O. SVENSSON, J. KARLSSON, U. KNUTSON, T. GASSLANDER, J. LINDHAGEN, G. ARBMAN, R. JANSSON, R. SANDSTRÖM, B. HULDT, B.-G. PETTERSSON, K.-G. JANUNGER, B. SJÖLUND, H. HERNQVIST |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Gastroenterology Internal medicine medicine Humans Pharmacology (medical) Cimetidine Adverse effect Omeprazole Aged Aged 80 and over Hepatology medicine.diagnostic_test business.industry Significant difference Antagonist Middle Aged Endoscopy Duodenal ulcer Duodenal Ulcer Female Once daily business medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 2:483-492 |
| ISSN: | 1365-2036 0269-2813 |
| DOI: | 10.1111/j.1365-2036.1988.tb00721.x |
| Popis: | SUMMARY In a Swedish double-blind multicentre study, omeprazole (30 mg o.m.) was compared with the H2-receptor antagonist cimetidine (400 mg b.d.) in 152 patients. Clinical assessments and laboratory investigations were carried out at 2 and 4 weeks, and again at 6 weeks in unhealed patients. Endoscopy was performed at 2 weeks, and again at 4 and 6 weeks in unhealed patients. The patients in the two groups were well-matched prior to treatment. Omeprazole was superior to cimetidine in ulcer-healing rate after 2, 4 and 6 weeks. After 2 weeks of treatment, 66% of the omeprazole- and 45 % of the cimetidine-treated patients were healed (P= 0.02), after 4 weeks 97 and 84% (P= 0.01), and after 6 weeks 100 and 92% (P= 0.02), respectively. There was a more pronounced improvement in the patients' symptoms in the omeprazole group after 2 weeks (P= 0.05). Both drugs were well-tolerated, but there was a high prevalence of patients with adverse events in the cimetidine group (51%, compared to 30% of the omeprazole group; P= 0.02). A total of 125 patients were followed for 6 months after healing. The patients were investigated by endoscopy after 6 months, or whenever symptoms occurred. There was no significant difference in the rate of relapse within 6 months between the two treatment groups: 54% relapsed in the omeprazole group and 52 % in the cimetidine group. In conclusion, 30 mg of omeprazole, given once daily, is superior to 400 mg of cimetidine twice daily in duodenal ulcer healing; but ulcer relapse in the two groups appears to be equivalent. |
| Databáze: | OpenAIRE |
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