Epicardial adipose tissue volume as a marker of coronary artery disease severity in patients with diabetes independent of coronary artery calcium: Findings from the CTRAD study
| Autor: | Khiet C. Hoang, Farhood Saremi, Christine Le, Shaista Malik, Dilbahar Mohar, Shivesh Kumar, Nassim Naderi, Jonathan Salcedo, Ashwini Erande, Pradeep Nadeswaran |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Adipose tissue Coronary Artery Disease Coronary Angiography Severity of Illness Index Article Coronary artery disease Endocrinology Calcinosis Diabetes mellitus Internal medicine Multidetector Computed Tomography Severity of illness Internal Medicine Humans Medicine Pericardium cardiovascular diseases Retrospective Studies Computed tomography angiography medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Coronary Vessels medicine.anatomical_structure Adipose Tissue Diabetes Mellitus Type 2 Cardiology Calcium Female Tomography X-Ray Computed business Biomarkers Mace Follow-Up Studies |
| Zdroj: | Diabetes Research and Clinical Practice. 106:228-235 |
| ISSN: | 0168-8227 |
| Popis: | The association between epicardial adipose tissue (EAT) volume and coronary artery disease (CAD) severity was evaluated, independent of traditional risk factors and coronary artery calcium (CAC) scores, in patients with diabetes type 2 (DM-2) using cardiac computed tomography angiography (CTA).A multivariate analysis was utilized to assess for an independent association after calculating EAT volume, CAD severity, and calcium scores in 92 patients with DM-II from the CTRAD study. We graded CAD severity as none (normal coronaries), mild-moderate (70% stenosis), and severe (70% or greater stenosis).A total of 39 (42.3%) asymptomatic patients with diabetes did not have CAD; 30.4% had mild/moderate CAD; and 27.1% had severe CAD. Mean EAT volume was highest in patients with severe CAD (143.14 cm(3)) as compared to mild/moderate CAD (112.7 cm(3)), and no CAD (107.5 cm(3)) (p = 0.003). After adjustment of clinical risk factors, notably, CAC score, multivariate regression analysis showed EAT volume was an independent predictor of CAD severity in this sample (odds ratio 11.2, 95% confidence interval 1.7-73.8, p = 0.01).Increasing EAT volume in asymptomatic patients with DM-II is associated with presence of severe CAD, independent of BMI and CAC, as well as traditional risk factors. |
| Databáze: | OpenAIRE |
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