Effect of excessive gestational weight on daughters’ breast density at the end of puberty onset
| Autor: | Ana Pereira, María Luisa Garmendia, Camila Corvalán, John A. Shepherd, Ana López, Karin B. Michels |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Offspring Birth weight Inheritance Patterns lcsh:Medicine Mothers Overweight Article Nuclear Family 03 medical and health sciences Medical research Absorptiometry Photon 0302 clinical medicine Pregnancy medicine Humans Longitudinal Studies Obesity Sexual Maturation 030212 general & internal medicine Chile lcsh:Science Child Mammary Glands Human Cancer Breast Density Multidisciplinary Obstetrics business.industry lcsh:R medicine.disease Gestational Weight Gain body regions Logistic Models 030220 oncology & carcinogenesis Cohort Gestation lcsh:Q Female medicine.symptom business Weight gain Mammography |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| ISSN: | 2045-2322 |
| Popis: | The effect of excessive gestational weight gain (EGWG) is related to adverse health outcomes in the offspring; however, its effect on the daughters’ breast density is unclear. We aimed to assess the association between EGWG and daughters’ breast composition (% of fibroglandular volume (%FGV) and absolute fibroglandular volume (AFGV)) at Tanner stage 4 (Tanner B4)). We included 341 girls and their mothers from an ongoing cohort of low-income Chilean girls born from 2002–2003. Maternal gestational weight gain was self-reported in 2007, and breast density by digital mammography was measured in 2010. Weight, height and breast composition by dual X-ray absorptiometry (DXA) were measured in daughters at Tanner B4. Logistic regression models were run to assess the association between EGWG and the 80th percentile of %FGV and AFGV. Mean gestational weight gain was 13.7 kg (SD = 6.9 kg). Women with pregestational overweight or obesity exceeded the recommended gestational weight gain (58.8% vs. 31.8%, respectively). Daughters of women who had EGWG had higher levels of AFGV (OR: 2.02; 95%CI 1.16–3.53) at Tanner B4, which could be explained by metabolic and hormonal exposure in utero. However, we did not observe an association with %FGV. |
| Databáze: | OpenAIRE |
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