Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit
| Autor: | Serhat Akin, Feza Korkusuz, Nurşen Koç, Turgut Tokdemir, Alpaslan Senkoylu, Petek Korkusuz, Muharrem Timuçin, Cenk Balcik |
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| Rok vydání: | 2007 |
| Předmět: |
Calcium Phosphates
Ceramics Time Factors Tomography Scanners X-Ray Computed Materials science Biomedical Engineering Biocompatible Materials Biochemistry law.invention Weight-Bearing Biomaterials Intramedullary rod X-Ray Diffraction Flexural strength Bone Density In vivo law Materials Testing Animals Longitudinal Studies Ceramic Composite material Porosity Early weight bearing Molecular Biology Fixation (histology) Wound Healing General Medicine Radiography Disease Models Animal Durapatite visual_art Microscopy Electron Scanning visual_art.visual_art_medium Rabbits Implant Bone Diseases Biotechnology |
| Zdroj: | Acta Biomaterialia. 3:985-996 |
| ISSN: | 1742-7061 |
| Popis: | Porous interconnected hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) (60/40) ceramics are promising materials for hard tissue repair. However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA and HA/TCP (60/40) ceramics were used with intramedullary fixation in segmental bone defects of rabbits. Early radiological, histological, densitometric and biomechanical changes were evaluated. The mean radiological grade of healing and bonding to bone was higher in HA/TCP (60/40) ceramics than that of pure HA ceramics but the difference was not statistically significant. The densities of both implanted ceramics improved with time, supported by the histological evaluation of bone matrix ingrowth into ceramic pores, whereas the densities at the bone-ceramic interface decreased gradually. Flexural resonant frequencies and three-point bending strength increased, revealing an increase in mechanical stability during this early critical time interval where implant and/or bone-implant interface failures occur frequently. It can be concluded that both HA and HA/TCP (60/40) ceramics have a limited application in the treatment of load-bearing segmental bone defects but did not fail at the early stages of implantation. (C) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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