Lack of Association Between Polymorphisms in Dopa Decarboxylase and Dopamine Receptor-1 Genes With Childhood Autism in Chinese Han Population
| Autor: | Hong Yu, Jianjun Quan, Aiping Yang, Jun Liu, Heyue Lei, Zengyu Zhang, Wenjun Yang, Guohui Yang |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Genotype Single-nucleotide polymorphism Disease Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Polymorphism (computer science) medicine Humans Autistic Disorder Child Allele frequency Genetic Association Studies Genetics Aromatic L-amino acid decarboxylase Receptors Dopamine D1 medicine.disease 030227 psychiatry Dopamine receptor Child Preschool Pediatrics Perinatology and Child Health Dopa Decarboxylase Autism Female Neurology (clinical) Psychology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Child Neurology. 31:560-564 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073815601496 |
| Popis: | Genetic factors play an important role in childhood autism. This study is to determine the association of single-nucleotide polymorphisms in dopa decarboxylase ( DDC) and dopamine receptor-1 ( DRD1) genes with childhood autism, in a Chinese Han population. A total of 211 autistic children and 250 age- and gender-matched healthy controls were recruited. The severity of disease was determined by Children Autism Rating Scale scores. TaqMan Probe by real-time polymerase chain reaction was used to determine genotypes and allele frequencies of single-nucleotide polymorphism rs6592961 in DDC and rs251937 in DRD1. Case-control and case-only studies were respectively performed, to determine the contribution of both single-nucleotide polymorphisms to the predisposition of disease and its severity. Our results showed that there was no significant association of the genotypes and allele frequencies of both single-nucleotide polymorphisms concerning childhood autism and its severity. More studies with larger samples are needed to corroborate their predicting roles. |
| Databáze: | OpenAIRE |
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