Contribution of class I HLA-A2 antigen in immune reactions
| Autor: | Tirza Klein, Z. Ben-Rafael, D. Vardimon, Ella Livni, Jacob Hart, J. Notmann, L. Komlos, Isaac Halbrecht |
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| Rok vydání: | 1995 |
| Předmět: |
Cytotoxicity
Immunologic Graft Rejection Male Fetus Immunity Cellular Sex Characteristics General Medicine Human leukocyte antigen Biology Antigen Allograft rejection Pregnancy Virus Diseases HLA-A2 Antigen Neoplasms Immunology Cytotoxic T cell Humans Transplantation Homologous Female Immune reaction Allele Maternal-Fetal Exchange T-Lymphocytes Cytotoxic |
| Zdroj: | Medical hypotheses. 45(1) |
| ISSN: | 0306-9877 |
| Popis: | The involvement of the Class I HLA-A2 antigen is briefly reviewed in relation to allograft rejection, the feto-maternal relationship, viral cytotoxic reactions and tumor immunity. It is suggested that the HLA-A2 molecule may have, as compared to other HLA Class I alleles, a dominant role as a restricting element in cytotoxic T-cell recognition in the feto-maternal relationship to male fetuses, in specific viral infections and in tumors. As compared to other HLA Class I alleles, its reduced expression or loss in a variety of tumors suggests its possible important role in tumor immune surveillance. The disappearance of HLA-A2 from tumor cells may eventually contribute to the escape from T-cell recognition of malignant cells. |
| Databáze: | OpenAIRE |
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