Synthesis and evaluation of naphthalene-based thiosemicarbazone derivatives as new anticancer agents against LNCaP prostate cancer cells
| Autor: | Zafer Asım Kaplancıklı, Goekhan Kus, Belgin Sever, Selda Kabadere, Ahmet Özdemir, Pinar Oztopcu-Vatan, Mehlika Dilek Altıntop |
|---|---|
| Přispěvatelé: | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Altıntop, Mehlika Dilek, Sever, Belgin, Özdemir, Ahmet, Kuş, Gökhan, Kaplancıklı, Zafer Asım |
| Rok vydání: | 2015 |
| Předmět: |
Male
Thiosemicarbazones Antineoplastic Agents Apoptosis Naphthalenes urologic and male genital diseases Thiosemicarbazone Structure-Activity Relationship chemistry.chemical_compound Prostate cancer Drug Discovery LNCaP Tumor Cells Cultured medicine Humans Cytotoxic T cell MTT assay Semicarbazone Cell Proliferation Naphthalene Pharmacology Dose-Response Relationship Drug Molecular Structure Prostatic Neoplasms General Medicine Flow Cytometry medicine.disease Biochemistry chemistry Cancer cell Cancer research Drug Screening Assays Antitumor Lncap Cells |
| Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry. :1-7 |
| ISSN: | 1475-6374 1475-6366 |
| Popis: | WOS: 000372017000008 PubMed ID: 25826149 Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay indicated that compounds 6, 8 and 11 exhibited inhibitory effect on LNCaP cells. Among these compounds, 4-(naphthalen-1-yl)-1-[1-(4-hydroxyphenyl)ethylidene)thiosemicarbazide (6), which caused more than 50% death on LNCaP cells, was chosen for flow cytometric analysis of apoptosis. Flow cytometric analysis pointed out that compound 6 also showed apoptotic effect on LNCaP cells. Compound 6 can be considered as a promising anticancer agent against LNCaP cells owing to its potent cytotoxic activity and apoptotic effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|