Tetradecylthioacetic Acid Increases Fat Metabolism and Improves Cardiac Function in Experimental Heart Failure

Autor: Christen P. Dahl, Jan Otto Beitnes, Erik Øie, Pavol Bohov, Arne Yndestad, Pål Aukrust, Thor Edvardsen, Thor Ueland, Rolf K. Berge
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
medicine.medical_specialty
Clinical chemistry
Myocardial Infarction
Sulfides
030204 cardiovascular system & hematology
Biology
Biochemistry
Antioxidants
Fats
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Fatty Acids
Omega-6
Internal medicine
Fatty Acids
Omega-3
medicine
Animals
Myocardial infarction
Rats
Wistar
030304 developmental biology
Heart Failure
2. Zero hunger
chemistry.chemical_classification
0303 health sciences
Cholesterol
Myocardium
Organic Chemistry
Hemodynamics
Fatty acid
Tetradecylthioacetic acid
Heart
Cell Biology
Lipid Metabolism
medicine.disease
Lipids
Rats
3. Good health
Endocrinology
chemistry
Heart failure
Myocardial infarction complications
lipids (amino acids
peptides
and proteins)
sense organs
Oxidation-Reduction
Polyunsaturated fatty acid
Zdroj: Lipids; Vol 48
ISSN: 0024-4201
DOI: 10.1007/s11745-012-3749-z
Popis: Changes in myocardial metabolism, including a shift from fatty acid to glucose utilization and changes in fatty acid availability and composition are characteristics of heart failure development. Tetradecylthioacetic acid (TTA) is a fatty acid analogue lacking the ability to undergo mitochondrial β-oxidation. TTA promotes hepatic proliferation of mitochondria and peroxisomes and also decreases serum triglycerides and cholesterol in animals. We investigated the effect of TTA, in combination with a high-fat or regular diet, in a rat model of post-myocardial infarction heart failure. TTA had a beneficial effect on cardiac function in post-myocardial infarction heart failure without affecting myocardial remodeling. These effects of TTA on myocardial function were accompanied by decreased free fatty acids in plasma, increased myocardial proportion of n-3 polyunsaturated fatty acids (PUFA) and a decreased proportion of n-6 PUFA. Myocardial enzyme gene expression during TTA treatment suggested that the increase in n-3 PUFA could reflect increased n-3 PUFA synthesis and inadequately increased n-3 PUFA β-oxidation. Based on our data, it is unlikely that the changes are secondary to alterations in other tissues as plasma and liver showed an opposite pattern with decreased n-3 PUFA during TTA treatment. The present study suggests that TTA may improve myocardial function in heart failure, potentially involving its ability to decrease the availability of FFA and increase the myocardial proportion of n-3 PUFA.
Databáze: OpenAIRE
Externí odkaz: