Voluntary exercise reduces plasma cortisol levels and improves transitory memory impairment in young and aged Octodon degus
| Autor: | Consuelo Sanchez-Rodrigo, Ana González-Cuello, Lorena Cuenca, Maria Herrero, Lorena Cano-Fernandez, Cristina Estrada, Emiliano Fernández-Villalba, Ana Luisa Gil-Martinez |
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| Rok vydání: | 2019 |
| Předmět: |
Hydrocortisone
Physical Exertion Physiology Disease Hippocampus 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Cognition Alzheimer Disease Memory biology.domesticated_animal medicine Dementia Memory impairment Animals Cognitive Dysfunction 030304 developmental biology 0303 health sciences Sleep disorder Memory Disorders biology business.industry Age Factors Brain medicine.disease Octodon degus Barnes maze Octodon Sleep deprivation Disease Models Animal Sleep Deprivation Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Behavioural brain research. 373 |
| ISSN: | 1872-7549 |
| Popis: | Sleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer's disease (AD). SD emulates many aging-related modifications, including important memory dysfunctions possibly caused by triggers of stress such as cortisol. Although exercise is widely assumed to be beneficial for overall health, only recently has the research community focused its attention on its possible effects on brain functions such as cognition. Octodon degus (O. degus) is a recent rodent model considered suitable for the study of neurodegenerative diseases, since it spontaneously develops several histopathological hallmarks observed in AD. We aimed to uncover the interaction between stress, exercise, age and transient memory impairments after SD insult. In this study, animals had free individual access to wheels to practice voluntary exercise. The Barnes Maze (BM) task was conducted with young and aged O. degus animals after combining voluntary exercise and either normal sleep or SD. Plasma cortisol levels were measured after each condition. SD impaired hippocampus-dependent memory in both young and old animals, while cortisol levels did not significantly differ between non-SD and SD animals. However, voluntary exercise for 45 days improved the cognitive impairment caused by SD compared with the control condition. Moreover, voluntary exercise decreased plasma cortisol levels in both conditions, independently of the age. |
| Databáze: | OpenAIRE |
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