Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls
| Autor: | Mingao Wang, Changsong Wang, Hongshuang Tong, Yue Feng, Yue Wang, Lin Zhu, Enyou Li, Xin Pi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinalysis Glomerulonephritis Membranoproliferative Urinary system Urine Gastroenterology Article Gas Chromatography-Mass Spectrometry Nephropathy Young Adult Internal medicine medicine Humans Solid Phase Microextraction Kidney Principal Component Analysis Volatile Organic Compounds Multidisciplinary medicine.diagnostic_test business.industry Case-control study Discriminant Analysis Glomerulonephritis IGA Middle Aged medicine.disease Glomerular Mesangium medicine.anatomical_structure Endocrinology Case-Control Studies Mesangial proliferative glomerulonephritis Female Gas chromatography–mass spectrometry business Biomarkers |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep14744 |
| Popis: | Urinary volatile organic compounds (VOCs) analysis for kidney diseases has attracted a large amount of scientific interest recently and urinary metabolite analysis has already been applied to many diseases. Urine was collected from 15 mesangial proliferative glomerulonephritis (MsPGN) patients, 21 IgA nephropathy (IgAN) patients and 15 healthy controls. Solid phase microextraction–chromatography– mass spectrometry (SPME-GC-MS) was used to analyse the urinary metabolites. The statistical methods principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLSDA) were performed to process the final data. Five metabolites were significantly greater in the group of MsPGN patients than in the normal control group (P |
| Databáze: | OpenAIRE |
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