Postnatal early overfeeding induces cardiovascular dysfunction by oxidative stress in adult male Wistar rats
| Autor: | Marcos Divino Ferreira Junior, Rodrigo Mello Gomes, Flávio Andrade Francisco, Carlos Henrique Xavier, Carlos Henrique de Castro, Keilah Valéria Naves Cavalcante, Gustavo Rodrigues Pedrino, Paulo Cezar de Freitas Mathias, Paulo R. Lopes, Ângela Ribeiro Neves, Lucas Araújo Ferreira, Amanda de Sá Martins de Bessa, Carolina Nobre Ribeiro Pontes |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Metabolic imprinting Vascular Remodeling medicine.disease_cause Weight Gain 030226 pharmacology & pharmacy Cardiovascular System General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Overnutrition Ventricular hypertrophy Enos medicine.artery Internal medicine Renin–angiotensin system medicine Animals Obesity General Pharmacology Toxicology and Pharmaceutics Rats Wistar Receptor Aorta biology business.industry Myocardium Body Weight Heart General Medicine medicine.disease biology.organism_classification Rats Disease Models Animal Oxidative Stress 030104 developmental biology Endocrinology Blood pressure Animals Newborn Cardiovascular Diseases business Oxidative stress |
| Zdroj: | Life sciences. 226 |
| ISSN: | 1879-0631 |
| Popis: | Aims Obesity is associated with innumerous comorbidities, including cardiovascular diseases, that occur by various mechanisms, including hyperactivation of the renin angiotensin system, oxidative stress and cardiovascular overload. Postnatal early overfeeding (PO) leads to metabolic imprinting that induces weight gain throughout life, and in this paper, we aimed to evaluate cardiovascular parameters and cardiac molecular changes due to obesity induced early in life by PO. Main methods Male Wistar rats (120-days-old), raised in normal (NL) or small litters (SL), were submitted to cardiac assessment by transthoracic echocardiography and blood pressure evaluation. Thereafter, the hearts and aorta rings from these animals were submitted to ex-vivo isolated assays. Still, cardiac morphological and molecular analyses were performed. Key findings PO induced ventricular hypertrophy, raised blood pressure, increased fibrosis, and ex-vivo cardiac dysfunction in the SL group. Furthermore, SL animals presented impaired vascular relaxation and increased vascular constriction responses. Besides functional alterations, SL animals presented augmented RAB-1b and SOD-1, despite no changes in RAS receptors expression or Akt/eNOS pathway. Significance Taken together, our results consolidate the knowledge that the PO during lactation is critical for cardiometabolic programming, leading to oxidative stress and cardiac remodeling in later stages of life. |
| Databáze: | OpenAIRE |
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